Obesity

Expenditures tied to underweight and obesity totaled $1 billion and $2.4 billion in 2018

Or else run the risk of aspirating under anesthesia due to delayed gastric emptying

But GI side effects higher than other comparable anti-obesity agents

Tool is still useful, but should be used in concert with other measures, experts suggest

Some people just don't respond; others have such severe side effects they need to stop

Once-weekly CagriSema reduced body weight more than either agent alone

Another study showed two high doses were better at reducing HbA1c vs a 14-mg dose

Plus, two other studies on retatrutide show benefit in type 2 diabetes, fatty liver disease

Daily orforglipron also lowered HbA1c in type 2 diabetes

Some more highlights from the Endocrine Society's annual meeting

Survivors on aromatase inhibitors lost significantly less weight

The first step is "acknowledging it, supporting, and listening," researcher says

Clinicians should not rely solely on BMI for measuring obesity, researcher says

Metreleptin doses several times higher than recommended brought weight down to near normal